Happening at the DuPuis reserve on the edge of Palm Beach County, the man was left for almost an hour as rescuers struggled to find him as he lay slumped in long grass.
The 10 foot gator left the victim with shocking wounds that required immediate medical attention, according to rescue crews on the scene.
A helicopter from the nearby Martin County Fire Rescue, took the man to St Mary’s Medical Centre for treatment.
His condition since the incident remains “unknown” as well as his reasons for being in the reserve, but the area is popular with hunters, anglers and campers.
Authorities have now launched an investigation into the alligator attack which happened on Saturday afternoon.
Alligators have inhabited Florida’s marshes, swamps, rivers and lakes for many centuries, and are found in all 67 counties.
Many residents seek waterfront homes, and this results in more frequent attacks on humans from alligators.
American alligators occasionally prey on large mammals, such as deer, but usually do so only when fish and smaller prey levels go down.
If one bites you, the advice is to make the most noise possible and work hard to get away.
People are cautioned to even use force if necessary.
In May, a 10-year-old girl freed herself from the jaws of a giant alligator using a technique learned during a show at a nearby theme park.
Experts praised the girl’s quick thinking.
Gatorland spokesperson Donald Aldarelli said: “To get an animal with the strongest bite on the planet to let go of you is a miracle.
“I’m just happy that she heard it here.”
The alligator has since been captured and killed by trappers in the area.
This alligator attack comes after a surfer from Florida managed to escape injury after jumping off his surfboard on top of a shark.
Amazingly, the unnamed 27-year-old man received minor cuts and was treated at the scene after the bizarre incident.